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Upneeq, Rx

An Eye-Opening Lift with a Daily Drop of Upneeq
Upneeq is a prescription medication and must be dispensed in office.
  • Product Details

    Upneeq is the only FDA-approved prescription eyedrop for acquired ptosis (low-lying lids) that lifts your upper eyelids to open your eyes. 

    If your eyes look "tired" or "sleepy," you may have a condition called acquired blepharoptosis (also known as acquired ptosis or low-lying lids).  Millions of people over the age of 40 may have acquired ptosis, but only 15% have been diagnosed - and even fewer have received any treatment.  Acquired ptosis is a common medical condition that:

    • Can develop later in life
    • Affects adults of all ages, but occurs more often with increased age
    • Usually occurs when the muscles in the eyelid stretch and weaken, causing the upper eyelid to droop
    • May be caused by other issues, such as cataract surgery, contact lens wear, or an underlying medical condition.  It could also be a sign of a more serious medical condition.

    Low-lying eyelids can affect eyesight by not only blocking your vision, but also reducing field of vision, which may interfere with day-to-day functions such as:

    • Reading
    • Driving
    • Computer use
    • Looking up without the need to tilt your head back

    Treatment Type

    Prescription Eyedrop

    Size - 45 single-use vials
  • Usage

    Apply Upneeq to your affected eye(s) in 2 easy steps.

    Step 1: Cut open the foil wrapper and remove single-use vial

    Step 2: Apply one drop of Upneeq in each affected eye as directed, once a day

    • Do not let the tip of the vial touch your eye or any other surface
    • Vials should not be reused after opening and should be thrown away after applying drop(s)

    If you wear contact lenses, remove them before applying Upneeq drops.  You may put them back in 15 minutes after applying Upneeq.

    If more than one topical ophthalmic drub is being used, the drugs should be administered at least 15 minutes between applications.

    Upneeq should only be used as directed

    • Upneeq is designed to only be applied as an eyedrop
    • Each vial contains enough Upneeq solution to allow for one drop in each affected eye
    • The solution should never be swallowed or ingested in any other way
    • Storage requirements: Upneeq should be stored at 68°F-77°F (20°C-25°C) and should be protected from excessive heat
    • Keep out of reach of children
    • For complete instructions on using Upneeq, please see the Instructions for Use section in the full Prescribing Information

  • FAQ

    What is UPNEEQ?

    UPNEEQ® (oxymetazoline hydrochloride ophthalmic solution), 0.1% is a prescription eyedrop used to treat acquired blepharoptosis (low-lying lids) in adults.

    What warnings and precautions are associated with UPNEEQ?

    • Low-lying lids may be related to conditions such as stroke and/or brain aneurysm, Horner syndrome, myasthenia gravis, loss of the ability to move eye muscles, eye infection and eye tumors. Tell your doctor if you have any of these conditions.
    • UPNEEQ is a type of medication that may affect your blood pressure. If you have heart disease, uncontrolled high or low blood pressure, or feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.
    • Patients with reduced blood flow to the brain or heart, or patients who experience eye or mouth dryness due to an immune system disorder (Sjögren’s syndrome), should use care when taking UPNEEQ. Call your doctor immediately if you feel your symptoms may be getting worse.
    • UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
    • Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used.

    What are the most common side effects of UPNEEQ?

    The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.

    What should my doctor know about before prescribing me UPNEEQ?

    • Your doctor should review your full medical history before prescribing UPNEEQ.
    • UPNEEQ belongs to a class of medication (alpha-adrenergic agonists) that may affect your blood pressure. Use UPNEEQ carefully if you currently take an alpha-adrenergic agonist medication to treat heart disease or an enlarged prostate. Patients taking beta-blockers, or other medications to treat hypertension or an abnormal heartbeat, should also be careful when using UPNEEQ.
    • Patients who use a certain class of antidepressant medication (monoamine oxidase inhibitors) should also be careful when using UPNEEQ, as it may affect the way your body absorbs the medication.

    These are not all of the possible side effects of UPNEEQ. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects.

    To report side effects or product complaints, contact RVL Pharmaceuticals at 1-877-482-3788. You may also report side effects to the FDA by calling 1-800-FDA-1088 or visit

    This is a summary of the most important safety information for UPNEEQ. For more in-depth safety information, please review the full Prescribing Information for UPNEEQ.

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Upneeq, Rx

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