A.G.E. Interrupter Advanced is a multi-corrective cream clinically proven to improve visible signs of accelerated aging by preventing the multi-phase glycation process and supporting collagen integrity. Backed by 15+ years of glycation expertise and formulated with more potent and efficacious ingredients than its predecessor (A.G.E. Interrupter), this next-generation cream goes beyond traditional anti-aging skincare to smooth visible wrinkles, restore firmness, and enhance skin's radiance to counter dull and sallow tone. A.G.E. Interrupter Advanced features a rich, dry-finish texture, is suitable for all skin types and tones, and can be used alone or in conjunction with other corrective treatments and moisturizers.
What is Glycation?
Glycation, a key factor of intrinsic aging, occurs when excess glucose molecules bind to structural proteins, such as collagen and elastin. This multi-phase process is accelerated by external aggressors, including UV and pollution, which cause oxidative stress. As glycation progresses, crosslinking occurs and forms a ladder-like structure, causing collagen and elastin to become rigid and brittle, and resulting in Advanced Glycation End-Products (A.G.E.s).
A.G.E.s further damage skin cells, degrading their reparative ability and triggering
an inflammatory response.
Once or twice daily, massage a thin, even layer onto the entire face, neck, and chest. If using in the morning, apply after a SkinCeuticals vitamin C antioxidant serum and before a SkinCeuticals sunscreen. If using with a retinol at night, apply after retinol application.
18% CONCENTRATED PROXYLANE
Helps correct visible wrinkles and laxity by stimulating collagen VII and supporting its environment, delivering 6x more than the minimum effective dose known to activate glycosaminoglycans (GAGs).
4.25% WILD FRUIT FLAVONOIDS
Antioxidant blend of blueberry and pomegranate extracts helps inhibit protein glycation, including UV-induced glycation, and protect against free radical damage.
0.1% GLYCYRRHETINIC ACID
Therapeutic anti-inflammatory helps enhance the skin's natural radiance to counter dull and sallow tone, which may be linked to A.G.E. accumulation.